Mexican Chicken Casserole smothered in a simple sour cream, green chili and cheese sauce. The bubbly cheese sauce seals in the chicken juices so it bakes up tender, juicy and flavorful. Everyone needs an easy chicken bake for unexpected company. You won’t believe the easy sauce!

Some of our favorite recipes are Mexican-inspired like Ceviche, or Fish Tacos (the #1 recipe on our site right now). This chicken bake satisfies the craving for Mexican food.

Mexican Chicken Casserole garnished with avocado, tomato and cilantro

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Mexican Chicken:

We love easy Mexican chicken recipes. They are a fun way to explore new flavor combinations and change up your dinner routine. The green chilis give this really great flavor without being spicy. This Mexican Chicken Casserole is also a really easy party dish. The kids loved it because it was creamy, cheesy and the green chilis were very mild.

One of our readers, Judy, wrote in and shared this recipe with us and it was an instant hit. Thank you Judy! We really can’t get enough of this 3-ingredient sauce:

Ingredients for Chicken Casserole

Tips for Making Mexican Chicken Casserole:

Even though this is a crazy easy recipe, here are some pitfalls to avoid (because I know it’s super tempting to improvise with an easy recipe):

  • Don’t overload the chicken in the casserole dish. Increase everything proportionally and use a larger baking dish if scaling up the recipe.
  • Arrange Chicken in a single layer in the casserole dish – you want the sauce to cover each piece of chicken.
  • Don’t over-bake or the chicken will get dry. Remember the chicken is already cooked through.
  • Use green chilis with their juice – do not drain.

Step by step instructions for making Mexican chicken casserole

The avocado, tomato, cilantro garnish is optional but highly necessary. You can also serve this with fresh Pico de Gallo. We love this Mexican Chicken Casserole served over white rice.

Baked Mexican Chicken Casserole with fresh tomatoes and avocados on top

More Mexican-Inspired Recipes:

Watch Natasha Make Mexican Chicken:

I hope you love this easy peasy chicken bake! Let me know what are YOUR favorite Mexican foods in a comment below.

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Natasha's Kitchen Cookbook

Mexican Chicken Casserole

5 from 110 votes
Author: Natasha Kravchuk
Mexican Chicken Casserole on towel
Mexican Chicken Casserole smothered in a simple sour cream, green chili and cheese sauce. The bubbly cheese sauce seals in the chicken juices so it bakes up tender, juicy and flavorful.
Prep Time: 3 minutes
Cook Time: 27 minutes
Total Time: 30 minutes

Ingredients 

Servings: 8 people

Mexican Chicken Casserole:

  • 2 lbs chicken breasts, (4 small or 3 medium)
  • 1 tsp salt, or to taste
  • 1/4 tsp black pepper, or to taste
  • 8 oz shredded Mexican cheese, divided
  • 1 cup sour cream, (full fat)
  • 14 oz diced green chilis (two 7 oz can with their juice

To Serve:

  • 1 small avocado, diced
  • 1 roma tomato, diced
  • 2 Tbsp cilantro, chopped

Instructions

  • Preheat oven to 400˚F and butter a 9x13 casserole dish.
  • Cut chicken breasts in half lengthwise and season both sides with salt and pepper.
  • Place a large skillet over medium heat and add 2 Tbsp oil. Once oil is hot, add chicken in a single layer and cook about 3 minutes per side or until golden and just cooked through with an internal temperature of 165˚F. Cook chicken in 2 batches so you don’t overcrowd the pan and add more oil as needed.
  • Arrange sautéed chicken in buttered casserole dish so they are flat and not overlapping too much.
  • In a medium bowl, mix together 2/3 of your Mexican cheese, 1 cup sour cream and 2 cans of green chilis with their juice. Pour over chicken. Sprinkle the top with 1/3 remaining cheese and bake uncovered at 400˚F for 15 min or until cheese is melted and sauce is bubbling at the edges.
  • Serve garnished with diced avocado, tomatoes and chopped cilantro.

Nutrition Per Serving

338kcal Calories6g Carbs32g Protein21g Fat9g Saturated Fat114mg Cholesterol842mg Sodium680mg Potassium3g Fiber2g Sugar570IU Vitamin A22.2mg Vitamin C245mg Calcium1.4mg Iron
Nutrition Facts
Mexican Chicken Casserole
Amount per Serving
Calories
338
% Daily Value*
Fat
 
21
g
32
%
Saturated Fat
 
9
g
56
%
Cholesterol
 
114
mg
38
%
Sodium
 
842
mg
37
%
Potassium
 
680
mg
19
%
Carbohydrates
 
6
g
2
%
Fiber
 
3
g
13
%
Sugar
 
2
g
2
%
Protein
 
32
g
64
%
Vitamin A
 
570
IU
11
%
Vitamin C
 
22.2
mg
27
%
Calcium
 
245
mg
25
%
Iron
 
1.4
mg
8
%
* Percent Daily Values are based on a 2000 calorie diet.
Course: Main Course
Cuisine: Mexican
Keyword: mexican chicken casserole
Skill Level: Easy
Cost to Make: $
Calories: 338

If you make this recipe, I’d love to see pics of your creations on Instagram, Facebook and Twitter! Hashtag them #natashaskitchen

Natasha Kravchuk

Welcome to my kitchen! I am Natasha, the blogger behind Natasha's Kitchen (since 2009). My husband and I run this blog together and share only our best, family approved and tested recipes with YOU. Thanks for stopping by! We are so happy you're here.

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Recipe Rating




Comments

  • Barbara Cassidy
    February 22, 2024

    I made this, yesterday. Another winner, Natasha. My family loved it!

    Reply

    • NatashasKitchen.com
      February 22, 2024

      I’m so glad it was enjoyed.

      Reply

  • Gregory Pedigo
    July 15, 2023

    This is an easy and delicious weeknight meal and can easily be doubled for larger crowds. This casserole is a genius combination of few ingredients that makes a complete meal with a simple salad.

    Reply

    • Natashas Kitchen
      July 15, 2023

      I’m so glad you enjoyed it, Gregory!

      Reply

  • Shawnae
    March 16, 2023

    The Mexican Chicken Casserole is the bomb dot com! I served this dish with Black Beans and Rice and Pico de Gallo. This recipe is very easy to make, and took no time at all to prepare. Thank you for sharing your recipe, Ms. Natasha! 😋

    Reply

    • NatashasKitchen.com
      March 16, 2023

      I’m so glad you loved it, Shawnae! Thank you for the feedback. 🙂

      Reply

  • Katie
    March 10, 2023

    This was a quick and easy recipe! I feel that the avocado and tomato were a game changer! Another awesome recipe!

    Reply

    • Natashas Kitchen
      March 10, 2023

      Thank you for your lovely review, Katie! This is a must-have dish!

      Reply

  • Mark Kelleher
    September 22, 2022

    This was a total hit! Doubled the reciple and got positive comments from almost everyone who had it! Thanks again Natasha!

    Reply

    • Natashas Kitchen
      September 22, 2022

      That’s just awesome! Thank you for sharing your wonderful review, Mark! I’m so glad it was a hit!

      Reply

  • Nathasha
    June 13, 2022

    Hey Natasha! it’s me Nathasha!!! crazy right but hey! absolutely loved your recipe

    Reply

    • Natasha's Kitchen
      June 14, 2022

      Hello there Nathasha. Glad you loved this recipe, I hope you’ll enjoy all the recipes that you will try!

      Reply

  • Jeri Ann
    May 27, 2022

    I’ve made several times now. I do cut up the chicken and I add a can of black beans over the chicken before the sauce is added.

    Reply

    • NatashasKitchen.com
      May 27, 2022

      Sounds delicious! 🙂

      Reply

  • Ana Horta
    May 5, 2022

    I made this for my family tonight, served it with rice and pinto beans. It was a hit! Everyone loved it. Thank you for another amazing recipe!

    Reply

    • Natashas Kitchen
      May 5, 2022

      That’s just awesome! Thank you for sharing your wonderful review, Ana!

      Reply

  • Suzane Cole
    April 26, 2022

    will absolutely be trying this recipe–i will add taco seasoning to the chicken and put chopped green spring onion on top with all the other ingredients
    ps making Tiramisu later today–Thank You

    Reply

    • Natasha's Kitchen
      April 26, 2022

      Sounds like a great plan. Enjoy and I hope you’ll love all the recipes that you will try!

      Reply

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